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Neutral and cationic osmium(II)-arene metallodendrimers: Synthesis, characterisation and anticancer activity

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posted on 05.05.2020, 07:58 by Preshendren Govender, Fabio Edafe, Banothile C. E. Makhubela, Paul J. Dyson, Bruno Therrien, Gregory S Smith
Two neutral and two cationic half-sandwich Os(II)-arene metallodendrimers, of general formula [DABPPI-{(
g6-p-cym)Os((C7H5NO)-j2-N,O)Cl}n] and [DAB-PPI-{(g6-p-cym)Os((C6H5N2)-j2-N,N)Cl}n][PF6]n
(where n = 4 (G1) or 8 (G2)) have been synthesised. In addition, two cationic half-sandwich Os(II)-arene
metallodendrimers, containing PTA (1,3,5-triaza-7-phosphatricyclo[3.3.1.1.] decane), of general formula
[DAB-PPI-{(g6-p-cym)Os((C7H5NO)-j2-N,O)PTA}n][PF6]n are also reported. All complexes have been characterised
using analytical (i.e. HR-ESI or EI mass spectrometry and elemental analysis) and spectroscopic
(i.e. 1H, 13C{1H} NMR and infrared) methods. Model mononuclear analogues have been prepared and their
molecular structures determined by single-crystal X-ray crystallography. The cytotoxicity of the complexes
were evaluated against the A2780 and A2780cisR human ovarian carcinoma cell lines and some
display moderate activity.

Funding

University of Cape Town, the National Research Foundation (NRF) of South Africa

South African Medical Research Council (MRC), Deutscher Akademischer Austausch Dienst (DAAD)

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